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Diffuse cerebral edema may occur in severe cases

In an additional autoregressive analysis encompassing drugs with growing trends, prescriptions rates after January 1, 2021 can be generally forecasted using the recent historical trends in online searches (Supplementary Figure 1)

Semaglutide is a pure GLP-1 receptor agonist

Traditional intervention strategies have mainly focused on individual organelles, including scavenging mtROS, enhancing autophagy, and modulating nuclear factors [340]

These receptors are highly conserved and robustly characterized, as genetic knockouts in nonclinical species and human mutations result in similar obese phenotypes (85, 90, 101)